Polyclonal IgE Induces Mast Cell Survival and Cytokine Production

Activation in Mast Cells Cytokine Production and Fos and Jun Nitric Oxide Inhibits IgE-Dependent

IL-4 and -5 prime human mast cells for different profiles of IgE-dependent cytokine production.

Mast cells (MC) are stem cell factor-dependent tissue-based hematopoietic cells with substantial functional heterogeneity. Cord blood-derived human MC (hMC) express functional receptors for IL-5, and IL-5 mediates stem cell factor-dependent comitogenesis of hMC in vitro. Although IL-5 is not required for normal hMC development, we considered that it might prime hMC for their high-affinity Fc re...

IgE-mediated mast cell activation induces Langerhans cell migration in vivo.

Langerhans cells and mast cells are both resident in large numbers in the skin and act as sentinel cells in host defense. The ability of mast cells to induce Langerhans cell migration from the skin to the draining lymph node in vivo was examined. Genetically mast cell-deficient (W/Wv) mice and control mice were sensitized with IgE Ab in the ear pinna. Seven to 14 days later, mice were challenge...

Langerhans Cell Migration In Vivo IgE-Mediated Mast Cell Activation Induces

IL-33 induces IL-13 production by mouse mast cells independently of IgE-Fc RI signals

The IL-1-related molecules, IL-1 and IL-18, can promote Th2 cytokine production by IgE/antigen-Fc RI-stimulated mouse mast cells. Another IL-1-related molecule, IL-33, was identified recently as a ligand for T1/ST2. Although mouse mast cells constitutively express ST2, the effects of IL-33 on mast cell function are poorly understood. We found that IL-33, but not IL-1 or IL-18, induced IL-13 and...